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6 OMIM references -
6 associated genes
3 signs/symptoms

PROTEIN INTERACTIONS: 1

Hereditary sensory and autonomic neuropathy type 4

1 OMIM reference -
1 associated gene
9 signs/symptoms

Neuroblastoma

Hereditary sensory and autonomic neuropathy type 4

ALK	(UniProt - OMIM)		NTRK1	(UniProt - OMIM)
HACE1	(UniProt - OMIM)
LIN28B	(UniProt - OMIM)
MYCN	(UniProt - OMIM)
PHOX2B	(UniProt - OMIM)
TOP2A	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MYCN	(0.63)	NTRK1

Citations in the biomedical literature:

Neuroblastoma		Hereditary sensory and autonomic neuropathy type 4
	Synonym(s): - Neural crest tumor - Sympathoblastoma		Synonym(s): - HSAN4 - Insensitivity to pain - anhidrosis - NHSA4

	Classification (Orphanet): - Rare neurologic disease - Rare oncologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: childhood Average age of death: child / adolescent Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 6 OMIM references - 2 MeSH references: C536408 / D009447		External references: 1 OMIM reference - No MeSH references

Neuroblastoma		Hereditary sensory and autonomic neuropathy type 4
	Very frequent - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Organic acid metabolism anomalies Frequent - Autosomal dominant inheritance		Very frequent - Autosomal recessive inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Insensitivity to pain - Intellectual deficit / mental / psychomotor retardation / learning disability - Osteosclerosis / osteopetrosis / bone condensation - Psychic / behavioural troubles Occasional - Dental staining anomaly / spotted teeth / erythrodontia - Thick skin / pachydermia / orange skin - Tight skin / lack of elasticity